introduction: MDD overview
Understanding the impact of depression
Depression affects millions of people. But every patient with depression responds to treatment differently. For healthcare professionals seeking treatment options for their patients, Viibryd® is approved for the treatment of major depressive disorder (MDD) in adults.
Depression affects many…
- MDD is one of the top contributors to disability worldwide1
- MDD is one of the most common mental illnesses in the U.S., affecting almost 17 million adults2
In many different ways…
- MDD is a heterogeneous disease—every patient can present with different symptoms3
- Persistent depressed mood or loss of interest are common defining features of MDD3*
- Other MDD symptoms are also persistent and vary by patient3*
- Insomnia or hypersomnia
- Weight gain or weight loss; increase or decrease in appetite
- Psychomotor agitation or psychomotor retardation
- Fatigue or loss of energy
- Feelings of worthlessness or excessive/inappropriate guilt
- Diminished ability to think/concentrate or indecisiveness
- Recurrent thoughts of death/suicide or suicide attempt
MDD diagnosis requires 5 (or more) of the symptoms listed above, which must be present for at least 2 weeks, and represent a change from previous functioning. At least one of the symptoms must be either depressed mood or loss of interest or pleasure.4
Unmet needs still exist
According to the National Institute of Mental Health:
In the STAR*D Study
- Institute for Health Metrics and Evaluation. The global burden of disease, 2017 update. Geneva, Switzerland: The Lancet Press. IHME; 2018.
- Major depression. National Institute of Mental Health website. https://www.nimh.nih.gov/health/statistics/major-depression.shtml. Updated February 2019. Accessed December 7, 2021
- American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Washington, DC: American Psychiatric Association; 2013.
- Trivedi MH, Rush AJ, Wisniewski SR, et al. Am J Psychiatry. 2006;163:28-40.
- American Psychiatric Association. Practice guideline for the treatment
of patients with major depressive disorder. Third edition.
guidelines/guidelines/mdd.pdf. Published November 2010. Accessed December 7, 2021.